Tetrahydrobiopterin metabolic process

Across TCGA cell cohorts, RNA activity of the Tetrahydrobiopterin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUT4, CCHCR1, and AKT3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUT4 grouped by Tetrahydrobiopterin metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TUT4 →	-1.063	-1.511	.004	.001	3	5
LUNG_NSCLC_LUAD	CCHCR1 →	-0.762	-1.043	<.001	<.001	3	5
BONE	AKT3 →	-2.144	-1.664	.007	.002	2	6
BONE	MIS18BP1 →	-1.137	-1.912	.005	<.001	3	5
LUNG_SCLC	GPR176 →	-1.460	-1.134	.002	.002	3	5
BREAST	VIM →	-3.277	-0.967	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUT4 by Tetrahydrobiopterin metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →