Tetrahydrobiopterin metabolic process

Across TCGA cell cohorts, RNA activity of the Tetrahydrobiopterin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ULK3, GSR, and PLEKHH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrobiopterin metabolic process activity versus ULK3 in PANCREAS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ULK3 →	+0.621	+1.075	<.001	.001	3	6
OVARY	GSR →	+0.755	+1.195	.002	<.001	3	6
SKIN	PLEKHH1 →	+1.481	+0.841	<.001	.002	3	6
BREAST	PLCH1 →	+1.159	+0.682	<.001	.009	2	6
BREAST	PCBD1 →	+1.068	+1.001	.001	<.001	3	5
BONE	ARNTL2 →	-2.690	-1.674	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046146 vs ULK3 — PANCREAS

Explore this scatter interactively →