Negative regulation of vitamin metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of vitamin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, MAP1B_S614, and NAMPT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vitamin metabolic process activity versus WIPF1 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WIPF1 →	+0.341	+0.044	<.001	.003	3	6
LSCC	MAP1B_S614 →	+1.756	+0.090	<.001	<.001	3	6
BRCA	NAMPT →	+0.680	+0.055	.001	<.001	3	6
OV	CPXM1 →	+0.532	+0.040	.001	.004	3	5
UCEC	AKR1C3 →	+1.395	+0.090	<.001	<.001	3	5
COAD	ADA →	+0.407	+0.033	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046137 vs WIPF1 — BRCA

Explore this scatter interactively →