Negative regulation of vitamin metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of vitamin metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNMT3B, SIGLEC6, and ERCC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNMT3B grouped by Negative regulation of vitamin metabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNMT3B →	+0.196	+0.203	.003	.006	3	5
LUNG_NSCLC_LUAD	SIGLEC6 →	+0.134	+0.118	.004	.004	3	5
SOFT_TISSUE	ERCC2 →	+0.276	+0.197	.002	.002	3	4
KIDNEY	TNFRSF10D →	-0.218	-0.178	<.001	.004	3	4
LARGE_INTESTINE	AKR1C3 →	+0.151	+0.105	.003	.007	3	4
LUNG_NSCLC_LUAD	TDG →	+0.165	+0.144	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNMT3B by Negative regulation of vitamin metabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →