Negative regulation of vitamin metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of vitamin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C3, EXOSC5, and UBXN8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vitamin metabolic process activity versus AKR1C3 in LUNG_NSCLC_LUSC (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AKR1C3 →	+8.425	+2.227	.008	.004	2	5
BLOOD_Leukemia	EXOSC5 →	+0.657	+1.053	<.001	.004	3	4
LUNG_NSCLC_LUAD	UBXN8 →	+1.292	+1.329	.001	.001	3	3
LUNG_NSCLC_LUAD	VEGFD →	+0.871	+1.580	.001	<.001	3	3
LUNG_NSCLC_LUAD	SAMD5 →	+1.158	+1.250	.005	.003	3	3
OESOPHAGUS	NBPF14 →	-0.812	-1.590	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046137 vs AKR1C3 — LUNG_NSCLC_LUSC

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