Pyrimidine nucleoside catabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFI35, APOL3, and NMI, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside catabolic process activity versus IFI35 in HNSC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IFI35 →	+0.483	+0.067	<.001	<.001	3	9
HNSC	APOL3 →	+0.744	+0.083	<.001	<.001	3	9
HNSC	NMI →	+0.445	+0.075	<.001	<.001	3	9
OV	SERPINB9 →	+0.556	+0.073	<.001	<.001	3	8
BRCA	STAT1 →	+0.737	+0.071	<.001	<.001	3	8
GBM	TRIM21 →	+0.452	+0.075	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046135 vs IFI35 — HNSC

Explore this scatter interactively →