Pyrimidine nucleoside catabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR2, GFI1, and CSF2RB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside catabolic process activity versus CCR2 in HNSC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCR2 →	+1.042	+0.213	<.001	<.001	3	8
BRCA	GFI1 →	+0.580	+0.252	.001	.009	3	7
HNSC	CSF2RB →	+0.810	+0.194	<.001	<.001	3	7
HNSC	IL2RB →	+0.702	+0.176	<.001	<.001	3	7
HNSC	LPXN →	+0.715	+0.183	.004	<.001	3	7
HNSC	IL10RA →	+1.034	+0.211	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046135 vs CCR2 — HNSC

Explore this scatter interactively →