Pyrimidine nucleoside catabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP7D3, NKRF, and ZBTB17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP7D3 grouped by Pyrimidine nucleoside catabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MAP7D3 →	+1.349	+1.786	.001	.001	3	4
SKIN	NKRF →	+0.575	+0.321	.007	.003	3	3
CNS	ZBTB17 →	+2.360	+1.999	.002	<.001	2	4
CNS	RBM12 →	+1.128	+1.803	.008	<.001	3	3
LUNG_NSCLC_LUAD	GANAB →	+0.739	+0.776	<.001	.006	3	3
STOMACH	PAQR6 →	-1.640	-0.570	.005	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP7D3 by Pyrimidine nucleoside catabolic process activity — KIDNEY

Explore this box plot interactively →