Pyrimidine nucleoside catabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STRN4, NXF3, and AGXT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STRN4 grouped by Pyrimidine nucleoside catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	STRN4 →	-0.302	-1.579	.009	<.001	3	4
BONE	NXF3 →	-0.305	-1.700	<.001	<.001	3	4
BONE	AGXT →	-0.301	-1.644	<.001	<.001	3	4
SKIN	PRMT6 →	-0.200	-0.213	<.001	.004	3	4
LUNG_SCLC	ANLN →	+0.272	+1.562	.004	<.001	3	4
LUNG_SCLC	PKN3 →	-0.215	-1.486	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STRN4 by Pyrimidine nucleoside catabolic process activity — LUNG_SCLC

Explore this box plot interactively →