Pyrimidine nucleoside catabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRELD1, ACVR2B, and BOLA3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside catabolic process activity versus CRELD1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CRELD1 →	+1.840	+1.651	.003	.008	2	3
LUNG_NSCLC_LUAD	ACVR2B →	+0.732	+0.347	.003	.004	3	2
LUNG_NSCLC_LUAD	BOLA3 →	-0.972	-0.490	.001	<.001	3	2
LUNG_NSCLC_LUAD	NOS3 →	+3.628	+0.306	<.001	.002	3	2
LUNG_NSCLC_LUAD	FHL3 →	+0.892	+0.333	<.001	.001	3	2
LUNG_NSCLC_LUAD	ESPN →	+1.965	+0.338	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046135 vs CRELD1 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →