Purine ribonucleoside metabolic process

Across TCGA patient cohorts, RNA activity of the Purine ribonucleoside metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DTX3L, IFI35, and DCAF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleoside metabolic process activity versus DTX3L in LUAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DTX3L →	+0.291	+0.043	<.001	<.001	3	5
OV	IFI35 →	+0.441	+0.033	<.001	.003	3	5
BRCA	DCAF1 →	-0.229	-0.029	.001	.001	3	5
GBM	PLAA →	+0.461	+0.077	<.001	<.001	3	4
UCEC	TMEM43 →	-0.394	-0.063	<.001	.002	3	4
UCEC	MGRN1 →	-0.201	-0.058	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046128 vs DTX3L — LUAD

Explore this scatter interactively →