Purine ribonucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Purine ribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGM2, ADA, and CAMSAP3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleoside metabolic process activity versus PGM2 in KIDNEY (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PGM2 →	+1.011	+0.144	<.001	<.001	3	13
BLOOD_Leukemia	ADA →	+1.723	+0.154	<.001	<.001	3	13
BREAST	CAMSAP3 →	-1.981	-0.150	<.001	<.001	3	11
OESOPHAGUS	RPP40 →	+1.105	+0.129	.002	.001	3	10
BLOOD_Lymphoma	CHAC2 →	+0.867	+0.108	.004	.002	3	10
LARGE_INTESTINE	HPRT1 →	+0.682	+0.125	.006	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046128 vs PGM2 — KIDNEY

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