Purine ribonucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Purine ribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP1M1, PALLD, and KLF16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleoside metabolic process activity versus AP1M1 in LIVER (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AP1M1 →	+1.323	+1.506	.004	.009	3	5
OVARY	PALLD →	-1.468	-1.205	.001	<.001	3	4
OVARY	KLF16 →	+0.763	+1.097	.007	.005	2	5
OVARY	POLRMT →	+0.630	+0.961	.007	.003	3	4
PANCREAS	PRICKLE1 →	-1.647	-1.660	.003	<.001	3	4
KIDNEY	GGN →	-0.410	-1.513	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046128 vs AP1M1 — LIVER

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