Pyrimidine deoxyribonucleoside metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine deoxyribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT1, PFKFB4, and SLC43A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleoside metabolic process activity versus NUDT1 in GBM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NUDT1 →	+0.424	+0.089	<.001	.001	3	4
PDAC	PFKFB4 →	+0.688	+0.173	<.001	<.001	3	4
LUAD	SLC43A3 →	+0.705	+0.210	<.001	<.001	3	4
PDAC	SLC16A3 →	+0.660	+0.126	<.001	.005	3	4
HNSC	TPBG →	+0.887	+0.103	.003	.002	3	4
HNSC	EGFR →	+1.387	+0.109	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046125 vs NUDT1 — GBM

Explore this scatter interactively →