Pyrimidine deoxyribonucleoside metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine deoxyribonucleoside metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM6_S762, SAMHD1_T592, and SPTAN1_S1291, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleoside metabolic process activity versus MCM6_S762 in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM6_S762 →	+1.041	+0.153	<.001	<.001	3	4
GBM	SAMHD1_T592 →	+0.559	+0.080	<.001	<.001	3	3
OV	SPTAN1_S1291 →	-0.808	-0.176	<.001	<.001	3	3
LUAD	DPYD_S587 →	+0.818	+0.355	<.001	<.001	3	3
OV	EGFR_S991 →	+0.682	+0.154	<.001	<.001	3	3
GBM	HAT1 →	+0.382	+0.113	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046125 vs MCM6_S762 — GBM

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