Pyrimidine deoxyribonucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT9, SCHIP1, and NIPBL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACOT9 grouped by Pyrimidine deoxyribonucleoside metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACOT9 →	+0.679	+1.195	<.001	.001	3	4
LIVER	SCHIP1 →	+0.973	+1.131	.003	.008	3	4
BLOOD_Leukemia	NIPBL →	-0.410	-1.125	.008	<.001	3	4
BREAST	RPL29 →	+0.574	+0.714	.006	.004	3	4
LIVER	TSPAN5 →	+2.334	+1.332	.004	.001	3	4
LUNG_SCLC	MECR →	-0.791	-1.430	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACOT9 by Pyrimidine deoxyribonucleoside metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →