Pyrimidine deoxyribonucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine deoxyribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHCY, PHTF2, and LRP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine deoxyribonucleoside metabolic process activity versus AHCY in LARGE_INTESTINE (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AHCY →	+0.581	+0.193	.003	.007	2	6
SOFT_TISSUE	PHTF2 →	+0.677	+0.452	.006	.002	3	4
SOFT_TISSUE	LRP3 →	+2.707	+0.454	.002	.003	3	4
CNS	STX1A →	-1.499	-0.264	.008	<.001	3	4
BLOOD_Leukemia	S100A1 →	+1.263	+0.155	<.001	<.001	3	4
BLOOD_Leukemia	JAG2 →	+1.115	+0.116	.006	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046125 vs AHCY — LARGE_INTESTINE

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