Purine deoxyribonucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Purine deoxyribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB1, NOL7, and ERAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB1 grouped by Purine deoxyribonucleoside metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZBTB1 →	-0.844	-0.877	<.001	.005	3	4
STOMACH	NOL7 →	+0.567	+0.905	.006	.003	3	4
SOFT_TISSUE	ERAP1 →	+1.584	+1.655	.009	.002	3	4
PANCREAS	SSX2IP →	+0.886	+1.439	.005	.004	3	4
PANCREAS	SSB →	+0.794	+1.798	.002	<.001	3	4
BLOOD_Lymphoma	GTF2B →	+1.069	+2.143	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB1 by Purine deoxyribonucleoside metabolic process activity — STOMACH

Explore this box plot interactively →