Deoxyribonucleoside catabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAGH, TCF7, and ZNF687, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleoside catabolic process activity versus HAGH in BLOOD_Leukemia (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HAGH →	-0.743	-0.164	.002	.002	3	3
BLOOD_Leukemia	TCF7 →	-4.061	-0.125	<.001	.004	3	3
BLOOD_Myeloma	ZNF687 →	+0.911	+0.244	<.001	.001	3	3
BLOOD_Myeloma	ST3GAL2 →	+1.141	+0.244	.003	.001	3	3
BLOOD_Myeloma	NBPF20 →	+1.387	+0.244	<.001	.001	3	3
BLOOD_Myeloma	LIPT2 →	-0.677	-0.218	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046121 vs HAGH — BLOOD_Leukemia

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