Nucleobase catabolic process

Across TCGA patient cohorts, RNA activity of the Nucleobase catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRMP1, GDA, and NIP7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase catabolic process activity versus CRMP1 in BRCA (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRMP1 →	+0.643	+0.071	.003	<.001	3	6
HNSC	GDA →	+1.041	+0.076	<.001	.001	3	6
CCRCC	NIP7 →	-0.300	-0.117	<.001	<.001	3	6
CCRCC	ARHGEF12 →	+0.305	+0.118	<.001	<.001	3	5
BRCA	SEPTIN11 →	+0.320	+0.068	<.001	<.001	3	5
CCRCC	RPL5 →	-0.245	-0.118	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046113 vs CRMP1 — BRCA

Explore this scatter interactively →