Nucleobase catabolic process

Across TCGA patient cohorts, RNA activity of the Nucleobase catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMP1, MEIS3, and CNRIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase catabolic process activity versus EMP1 in OV (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EMP1 →	+0.813	+0.186	.009	.005	3	8
BRCA	MEIS3 →	+0.858	+0.120	<.001	<.001	3	7
OV	CNRIP1 →	+0.678	+0.214	.007	<.001	3	7
GBM	APBA1 →	+0.574	+0.176	<.001	.001	3	7
GBM	FEZ1 →	+0.622	+0.166	<.001	<.001	3	7
GBM	AK5 →	+1.602	+0.253	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046113 vs EMP1 — OV

Explore this scatter interactively →