Nucleobase catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleobase catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPYSL2, XDH, and CRMP1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPYSL2 grouped by Nucleobase catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DPYSL2 →	-0.478	-1.907	<.001	<.001	3	12
SKIN	XDH →	-0.203	-1.101	.004	.001	2	9
BREAST	CRMP1 →	-0.218	-1.017	.002	<.001	3	7
LARGE_INTESTINE	GDA →	-0.184	-1.500	.001	<.001	3	7
BLOOD_Myeloma	ZNF544 →	+0.303	+1.166	.006	.007	3	5
SKIN	CDKAL1 →	-0.216	-1.140	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPYSL2 by Nucleobase catabolic process activity — LIVER

Explore this box plot interactively →