Nucleobase catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleobase catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSC2, FNBP4, and CAND1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSC2 grouped by Nucleobase catabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TSC2 →	-1.271	-0.441	.006	.001	3	4
LUNG_SCLC	FNBP4 →	-0.694	-0.276	<.001	<.001	3	4
LUNG_SCLC	CAND1 →	-0.820	-0.268	<.001	<.001	3	4
BLOOD_Leukemia	PNKP →	-0.762	-1.533	.002	<.001	3	4
STOMACH	STK11IP →	-0.743	-0.541	<.001	.005	3	4
LUNG_NSCLC_LUAD	THOC5 →	+0.528	+0.299	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSC2 by Nucleobase catabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →