Nucleobase catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleobase catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSKR, ZNF781, and MAP3K20, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RSKR grouped by Nucleobase catabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RSKR →	-0.220	-0.258	.008	.005	2	3
BREAST	ZNF781 →	-0.164	-0.247	.008	.009	3	2
PANCREAS	MAP3K20 →	-0.218	-0.219	.008	.005	3	2
PANCREAS	ERCC6L →	-0.320	-0.236	<.001	.001	3	2
OESOPHAGUS	BMP8B →	-0.210	-1.711	.003	<.001	3	2
OESOPHAGUS	IL37 →	+0.319	+1.658	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RSKR by Nucleobase catabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →