Nucleobase biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleobase biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK2, FANCA, and MCM10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase biosynthetic process activity versus NEK2 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NEK2 →	+0.958	+0.188	.001	.002	3	5
BRCA	FANCA →	+0.479	+0.157	.006	.002	3	5
BRCA	MCM10 →	+1.016	+0.220	<.001	<.001	3	5
HNSC	POLD1 →	+0.740	+0.102	.003	.003	3	5
LSCC	GTPBP4 →	+0.361	+0.105	<.001	.001	3	5
LSCC	CENPA →	+0.534	+0.129	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046112 vs NEK2 — BRCA

Explore this scatter interactively →