Nucleobase biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleobase biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD13B, CTC1, and PGAM5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase biosynthetic process activity versus ANKRD13B in BONE (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ANKRD13B →	+2.364	+0.430	<.001	.007	3	6
BONE	CTC1 →	+1.144	+0.466	<.001	<.001	3	6
PANCREAS	PGAM5 →	+0.686	+0.309	.005	.002	3	6
BONE	CHERP →	+1.109	+0.526	<.001	<.001	3	6
BLOOD_Leukemia	ATP1A3 →	+2.704	+0.255	<.001	<.001	3	6
SKIN	RUVBL1 →	+0.780	+0.213	<.001	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046112 vs ANKRD13B — BONE

Explore this scatter interactively →