Inosine metabolic process

Across TCGA patient cohorts, RNA activity of the Inosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADA, ADA2, and C1QB, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inosine metabolic process activity versus ADA in SCLC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	ADA →	+1.569	+0.179	<.001	<.001	2	26
UVM	ADA2 →	+1.890	+0.052	<.001	<.001	2	25
UVM	C1QB →	+2.490	+0.074	<.001	<.001	3	22
THYM	ZAP70 →	+1.314	+0.046	<.001	.002	3	22
UVM	CD48 →	+2.023	+0.051	<.001	<.001	3	22
DLBC	C1QC →	+2.790	+0.138	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046102 vs ADA — SCLC

Explore this scatter interactively →