Inosine metabolic process

Across TCGA patient cohorts, RNA activity of the Inosine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COTL1, LCP2, and ELMO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inosine metabolic process activity versus COTL1 in COAD (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COTL1 →	+0.238	+0.039	.008	.006	3	5
GBM	LCP2 →	+0.306	+0.055	.002	<.001	3	5
GBM	ELMO1 →	+0.383	+0.059	<.001	.001	3	5
HNSC	TPK1 →	+0.418	+0.062	.001	<.001	3	5
HNSC	WIPF1 →	+0.358	+0.057	<.001	.001	3	5
LUAD	ADA →	+0.437	+0.060	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046102 vs COTL1 — COAD

Explore this scatter interactively →