Inosine metabolic process

Across TCGA cell cohorts, RNA activity of the Inosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COLGALT1, EDARADD, and CTSA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COLGALT1 grouped by Inosine metabolic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	COLGALT1 →	+1.239	+1.944	.008	<.001	3	4
BLOOD_Leukemia	EDARADD →	-1.580	-1.485	.005	<.001	3	4
BLOOD_Leukemia	CTSA →	+0.970	+1.094	.005	<.001	3	4
OVARY	CCPG1 →	+0.765	+0.627	.009	.004	3	4
OESOPHAGUS	TENT5C →	+0.722	+0.951	.002	.007	3	4
PANCREAS	IL10RB →	+0.628	+1.022	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COLGALT1 by Inosine metabolic process activity — BONE

Explore this box plot interactively →