Inosine metabolic process

Across TCGA cell cohorts, RNA activity of the Inosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM201, ZNF527, and ZNF724, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inosine metabolic process activity versus TMEM201 in BLOOD_Leukemia (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM201 →	+1.072	+0.282	<.001	.001	3	1
BLOOD_Leukemia	ZNF527 →	+0.787	+0.354	<.001	.004	3	1
BLOOD_Leukemia	ZNF724 →	+0.947	+0.261	.004	.004	3	1
BLOOD_Leukemia	ZNF681 →	+2.330	+0.434	<.001	<.001	3	1
BLOOD_Leukemia	STK40 →	+1.432	+0.329	.004	.005	3	1
BLOOD_Leukemia	SIRPB2 →	-4.215	-0.316	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046102 vs TMEM201 — BLOOD_Leukemia

Explore this scatter interactively →