Guanine metabolic process

Across TCGA patient cohorts, RNA activity of the Guanine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRTFDC1, TTC5, and TMEM119, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Guanine metabolic process activity versus PRTFDC1 in BRCA (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRTFDC1 →	+0.836	+0.100	<.001	<.001	3	8
OV	TTC5 →	+0.357	+0.113	.004	<.001	3	6
BRCA	TMEM119 →	-0.697	-0.084	<.001	<.001	3	5
UCEC	GDA →	+1.111	+0.130	<.001	<.001	3	5
LSCC	RCOR1 →	+0.380	+0.092	<.001	<.001	3	5
HNSC	SLC4A1AP_S312 →	+0.229	+0.080	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046098 vs PRTFDC1 — BRCA

Explore this scatter interactively →