Guanine metabolic process

Across TCGA patient cohorts, RNA activity of the Guanine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3GL1, TRIP10, and TPBG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Guanine metabolic process activity versus SH3GL1 in UCEC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SH3GL1 →	+0.318	+0.113	.001	.008	3	4
LSCC	TRIP10 →	+0.253	+0.148	.005	<.001	3	3
LSCC	TPBG →	+0.721	+0.195	<.001	<.001	3	3
PDAC	XDH →	+0.794	+0.125	<.001	<.001	3	3
LSCC	MT2P1 →	+0.414	+0.216	.005	<.001	3	3
LSCC	MIRLET7A2 →	-0.922	-0.182	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046098 vs SH3GL1 — UCEC

Explore this scatter interactively →