Guanine metabolic process

Across TCGA cell cohorts, RNA activity of the Guanine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKEF1, RABAC1, and TAS2R10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKEF1 grouped by Guanine metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ANKEF1 →	+1.027	+0.557	<.001	<.001	3	3
PANCREAS	RABAC1 →	+0.728	+1.462	<.001	.002	3	3
PANCREAS	TAS2R10 →	-0.466	-1.537	.005	.001	3	3
LARGE_INTESTINE	LAMTOR5 →	-0.427	-1.058	.008	.007	3	3
LARGE_INTESTINE	STYK1 →	+1.545	+0.986	<.001	.003	3	3
SOFT_TISSUE	TCEAL3 →	-2.171	-0.940	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKEF1 by Guanine metabolic process activity — SKIN

Explore this box plot interactively →