Cytidine metabolic process

pathway activity — cross-omics
GO:0046087Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cytidine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR5, LILRB2, and TRBV9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCCCR5 →+1.010+0.216.001<.00138
COADLILRB2 →+0.782+0.691.002.00338
BRCATRBV9 →+0.796+0.523.002.00937
HNSCTRAV13-1 →+0.903+0.150.001.00137
OVNCF1 →+1.006+0.788.001.00337
BRCAGBP5 →+1.382+0.682<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration