Adenosine metabolic process

Across TCGA patient cohorts, RNA activity of the Adenosine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIPK3, ASH2L, and PLIN3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenosine metabolic process activity versus RIPK3 in LSCC (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIPK3 →	+0.304	+0.049	.003	.001	3	6
GBM	ASH2L →	-0.254	-0.081	.002	<.001	3	5
GBM	PLIN3 →	+0.494	+0.109	<.001	<.001	3	5
GBM	PIP4K2A →	+0.425	+0.075	.004	.001	3	5
OV	DOK1 →	+0.229	+0.049	.005	.007	3	5
PDAC	SNX6 →	+0.143	+0.047	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046085 vs RIPK3 — LSCC

Explore this scatter interactively →