Adenosine metabolic process

Across TCGA patient cohorts, RNA activity of the Adenosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SESN2, CPA4, and XDH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenosine metabolic process activity versus SESN2 in PDAC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SESN2 →	+0.205	+0.112	.004	.002	3	4
HNSC	CPA4 →	+1.466	+0.129	.001	.003	3	4
LUAD	XDH →	+1.329	+0.175	<.001	.003	2	5
LUAD	ZNF706 →	-0.273	-0.204	.006	<.001	3	4
UCEC	GLUL →	+0.620	+0.140	.008	.003	3	4
UCEC	S100A9 →	+2.473	+0.124	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046085 vs SESN2 — PDAC

Explore this scatter interactively →