Adenosine metabolic process

Across TCGA cell cohorts, RNA activity of the Adenosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCP2, SKP1, and GPR63, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCP2 grouped by Adenosine metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PCP2 →	+0.440	+1.131	.009	.006	3	4
BLOOD_Myeloma	SKP1 →	+1.116	+1.734	.006	<.001	3	3
BONE	GPR63 →	-1.026	-1.842	.009	<.001	3	3
LUNG_SCLC	ELP3 →	+0.546	+1.178	.009	.001	3	3
LUNG_SCLC	RNF185 →	+0.844	+1.286	.002	.006	3	3
LUNG_SCLC	ATP5PD →	+0.785	+1.304	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCP2 by Adenosine metabolic process activity — OVARY

Explore this box plot interactively →