Adenosine metabolic process

Across TCGA cell cohorts, RNA activity of the Adenosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRCAP, ZNF808, and SNURF, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenosine metabolic process activity versus SRCAP in BLOOD_Leukemia (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SRCAP →	+1.285	+2.295	.001	<.001	3	2
BLOOD_Leukemia	ZNF808 →	+1.573	+1.981	.006	.001	3	2
BLOOD_Leukemia	SNURF →	+3.327	+2.048	.004	<.001	3	2
BLOOD_Leukemia	RHBDD3 →	+0.658	+1.804	.003	<.001	3	2
BLOOD_Leukemia	PLCG1 →	+2.450	+1.729	.001	<.001	3	2
BLOOD_Leukemia	BBS2 →	+1.167	+1.521	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046085 vs SRCAP — BLOOD_Leukemia

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