DTTP metabolic process

Across TCGA cell cohorts, RNA activity of the DTTP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMT2, C1orf21, and ERICH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NMT2 grouped by DTTP metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NMT2 →	-0.992	-0.860	.003	.008	3	4
LIVER	C1orf21 →	+3.344	+2.188	.006	<.001	3	4
SKIN	ERICH2 →	+1.130	+1.183	.006	.009	3	4
SKIN	RPL26L1 →	-0.904	-1.431	.003	<.001	3	4
SOFT_TISSUE	RNF152 →	+1.206	+1.412	.006	.007	3	4
BLOOD_Myeloma	DBP →	+1.469	+2.210	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NMT2 by DTTP metabolic process activity — BREAST

Explore this box plot interactively →