DTTP metabolic process

Across TCGA cell cohorts, RNA activity of the DTTP metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIFM1, RBM14, and ZBTB1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AIFM1 grouped by DTTP metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AIFM1 →	-0.264	-0.187	.001	.009	3	3
KIDNEY	RBM14 →	+0.466	+0.108	<.001	.005	3	3
LUNG_NSCLC_LUAD	ZBTB1 →	-0.144	-0.254	<.001	<.001	3	2
LUNG_NSCLC_LUAD	TRIM66 →	-0.199	-0.217	.003	.005	3	2
LUNG_SCLC	P2RX7 →	-0.456	-0.441	.002	.007	3	2
LARGE_INTESTINE	ATR →	-0.376	-0.204	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AIFM1 by DTTP metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →