CGMP catabolic process

Across TCGA patient cohorts, RNA activity of the CGMP catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CALD1_S202, TNS2, and TNS2_S120, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CGMP catabolic process activity versus CALD1_S202 in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CALD1_S202 →	+0.911	+0.091	.001	.004	3	8
BRCA	TNS2 →	+0.375	+0.044	<.001	<.001	3	8
LSCC	TNS2_S120 →	+0.601	+0.046	<.001	<.001	3	8
BRCA	ELN →	+0.841	+0.060	<.001	<.001	3	8
GBM	ABLIM2 →	+0.656	+0.095	<.001	<.001	3	8
BRCA	SGCD →	+0.645	+0.041	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046069 vs CALD1_S202 — CCRCC

Explore this scatter interactively →