CGMP metabolic process

Across TCGA patient cohorts, RNA activity of the CGMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01197, NR2F2-AS1, and LSM4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CGMP metabolic process activity versus LINC01197 in CCRCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LINC01197 →	+0.490	+0.763	.001	.001	2	7
LSCC	NR2F2-AS1 →	+0.528	+0.332	<.001	.001	3	5
OV	LSM4 →	-0.538	-0.715	.001	.001	3	5
PDAC	COL14A1 →	+1.051	+0.587	<.001	.005	3	5
CCRCC	JAM3 →	+0.865	+0.968	<.001	<.001	3	5
LSCC	PLXDC1 →	+0.459	+0.225	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046068 vs LINC01197 — CCRCC

Explore this scatter interactively →