CGMP metabolic process

Across TCGA cell cohorts, RNA activity of the CGMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIT, MC1R, and ARHGAP33, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CGMP metabolic process activity versus KIT in LUNG_NSCLC_LUAD (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KIT →	+2.610	+1.883	.007	<.001	3	3
LUNG_NSCLC_LUAD	MC1R →	+1.788	+1.730	.001	<.001	3	3
LUNG_NSCLC_LUAD	ARHGAP33 →	+1.308	+1.730	.007	<.001	3	3
OVARY	POLR2J2 →	+1.656	+1.741	.005	<.001	3	2
BREAST	SAA2 →	+2.915	+1.267	.001	<.001	3	2
BREAST	MRAP2 →	+1.329	+1.380	.002	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046068 vs KIT — LUNG_NSCLC_LUAD

Explore this scatter interactively →