CAMP metabolic process

Across TCGA patient cohorts, RNA activity of the CAMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE4B, TEK, and HSPG2, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CAMP metabolic process activity versus PDE4B in UCS (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	PDE4B →	+1.481	+0.063	<.001	<.001	3	31
UCS	TEK →	+1.405	+0.072	<.001	<.001	3	30
THYM	HSPG2 →	+2.155	+0.063	<.001	<.001	3	30
TGCT	ERG →	+1.258	+0.052	<.001	<.001	3	30
DLBC	SNRK →	+1.039	+0.056	<.001	<.001	3	30
DLBC	ZNF366 →	+0.946	+0.049	<.001	<.001	2	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046058 vs PDE4B — UCS

Explore this scatter interactively →