CAMP metabolic process

Across TCGA patient cohorts, RNA activity of the CAMP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX18, MPHOSPH10, and NAT10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CAMP metabolic process activity versus DDX18 in BRCA (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX18 →	-0.356	-0.038	<.001	<.001	3	7
OV	MPHOSPH10 →	-0.338	-0.034	.007	.006	3	7
BRCA	NAT10 →	-0.320	-0.028	<.001	<.001	3	7
OV	RRP15 →	-0.576	-0.042	.005	.007	3	7
LSCC	KDM3A →	-0.393	-0.046	<.001	.001	3	7
UCEC	ARHGEF17 →	+0.256	+0.044	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046058 vs DDX18 — BRCA

Explore this scatter interactively →