CAMP metabolic process

Across TCGA patient cohorts, RNA activity of the CAMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE4D, FAM122B, and LINC00174, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CAMP metabolic process activity versus PDE4D in LUAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PDE4D →	+1.163	+0.259	<.001	.001	3	5
CCRCC	FAM122B →	-0.298	-0.249	.009	.004	3	4
CCRCC	LINC00174 →	-0.330	-0.230	.003	.001	3	4
OV	RORA →	+0.447	+0.182	.004	<.001	3	4
PDAC	NPIPB12 →	-0.210	-0.209	.005	.004	3	4
LSCC	PRSS12 →	+0.996	+0.233	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046058 vs PDE4D — LUAD

Explore this scatter interactively →