CAMP metabolic process

Across TCGA cell cohorts, RNA activity of the CAMP metabolic process pathway is significantly associated with the drug response of multiple features, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are TAK-715, Enzastaurin, and Flavopiridol, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAK-715 grouped by CAMP metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TAK-715 →	+0.510	+2.082	.038	.002	2	3
SKIN	Enzastaurin →	+0.964	+2.154	.042	.011	1	3
SKIN	Flavopiridol →	-0.820	-2.154	.033	.011	1	3
CNS	FS106 →	+0.695	+1.449	.044	.037	3	1
CNS	BAY-MPS1 →	+1.104	+1.449	<.001	.037	3	1
CNS	Bleomycin (10 uM) →	+1.292	+1.449	.019	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAK-715 by CAMP metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →