DGMP metabolic process

Across TCGA patient cohorts, RNA activity of the DGMP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GDA, XDH, and FAM83H_S881, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DGMP metabolic process activity versus GDA in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GDA →	+1.208	+0.185	<.001	<.001	3	7
LSCC	XDH →	+1.121	+0.128	<.001	<.001	3	5
COAD	FAM83H_S881 →	+0.230	+0.046	.003	.001	3	5
UCEC	PDZK1IP1 →	+0.869	+0.150	<.001	<.001	3	5
HNSC	RPS6KA1_S363 →	+0.251	+0.119	<.001	<.001	3	5
UCEC	CMPK1 →	+0.407	+0.132	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046054 vs GDA — UCEC

Explore this scatter interactively →