DGMP metabolic process

Across TCGA patient cohorts, RNA activity of the DGMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XDH, HOXC11, and TDRD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DGMP metabolic process activity versus XDH in UCEC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XDH →	+1.863	+0.155	<.001	.004	3	5
LUAD	HOXC11 →	-0.864	-0.302	.001	<.001	3	4
COAD	TDRD5 →	-0.593	-0.377	.001	<.001	3	4
LUAD	DNAJC17 →	+0.431	+0.253	<.001	<.001	3	3
LUAD	VIL1 →	-1.973	-0.266	<.001	<.001	3	3
LUAD	KIF21A →	-0.556	-0.227	.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046054 vs XDH — UCEC

Explore this scatter interactively →