DGMP metabolic process

Across TCGA cell cohorts, RNA activity of the DGMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF320, IFITM10, and TPM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF320 grouped by DGMP metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF320 →	-1.740	-0.916	.001	.003	3	4
SOFT_TISSUE	IFITM10 →	-0.290	-1.409	.004	.004	3	4
KIDNEY	TPM1 →	-1.516	-1.463	<.001	<.001	3	4
BREAST	EBPL →	+0.790	+1.147	<.001	<.001	3	4
STOMACH	GPR146 →	-1.022	-1.341	<.001	.003	2	5
LUNG_NSCLC_LUSC	EMP3 →	-4.763	-1.238	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF320 by DGMP metabolic process activity — SKIN

Explore this box plot interactively →